 Citrus fruit has long been thought to be beneficial for health, but the exact mechanisms behind this were unclear. Researchers used the nematode kinohubditis elegans to study the effects of nomalin, a bitter-tasting limeloid found in citrus fruits, on lifespan and health span. They found that nomalin significantly increased the lifespan and health span of the worms, and that this effect was dependent on the insulin-like pathway DAF2, DAF16 and nuclear hormone receptors NHR8, DAF12. Further analysis revealed that nomalin also activates the human-pregnant X receptor, HPXR, which is the mammalian equivalent of NHR8, DAF12. Nomalin was shown to bind directly to HPXR, and when this interaction was disrupted, the lifespan-extending properties of nomalin were lost. Dietary supplementation with nomalin was then tested in two different mouse models of aging, and it was found to improve health span and lifespan in both cases. This article was authored by Xingjie Fan, Yingxian Yang, Yingxia, and others. We are article.tv, links in the description below.