 Thanks and so we're keeping pretty well on time and so at this point we will now transition to the last of our questions right before lunch and this will be question 4 and Carson Loomis will be framing the question on training sharing and collaboration. So I'm Carson Loomis I'll be framing question number four and to start I'll point out that obviously there's been a lot of interest in the undiagnosed disease network and that interest has been both national and international. It's also clinicians, physicians, clinical geneticists, as well as researchers all types of different researchers and so this question is specifically looking at communication, communication with the UDN and both international and national interactions and it's been broken down into three sections. The first section is training then sharing and then collaboration and in presenting today I'm gonna frame this and then Dr. Rachel Ramone is going to present on the UDN perspective for our outside expert perspective will be Dr. Ronald Kahn who's from the University of Toronto and then the moderator and summarizer will be Mariska Brown and specifically of those three areas I wanted to point out a couple specific points. One is that in training right now the NIH UDP and I think Rachel Ramone will speak more about this is doing specific types of training but the question is is that the right type of training and should that training be expanded or changed and also should the training be expanded to the rest of the network. For sharing of the information and data both the resources as well as the sharing of information and data with different databases such as DBGAP and FENTOM Central should that also be expanded beyond that is that adequate and for collaborations what role and level of support should collaborations have for clinical interactions should this should this expand to non-network clinical sites and that's in both directions as well as information going out but should it also be more of a collaboration with other clinical sites in the information and effort that they can bring in expand the international collaborations that have already be gone and for research the research aspect should we continue the gene function studies should those be expanded should the different cores model organisms and the metabolomics be more interactive with the program and also scientific collaborations with outside investigators are there ways in which we should expand and promote that type of further interaction going forward in the future and so I'll now turn it over to Rachel who will bring you up on the UDN perspective Rachel