 The prehable trial is a multi-center, multi-disciplinary, prospective, two-arm parallel group, randomized, controlled trial designed to evaluate the effectiveness of a structured, multimodal, multi-disciplinary prehabilitation program on reducing post-operative complications in patients with a proven fitness deficit undergoing major surgery. The primary outcome measure will be the comprehensive complication index, CCI, at 30 days. Overall, the study aims to enroll two-by-two 33 patients within three years who will be randomly assigned to either receive the prehabilitation program or standard of care. The intervention includes a structured, multimodal, multi-disciplinary approach to address deficiencies in physical fitness, nutrition, diabetes control, anemia management, and smoking cessation. The study is currently being conducted in Switzerland and is expected to conclude in 2025. This article was authored by Leah Balli, Martin Vera, Matthias Wilhelm, and others. We are article.tv, links in the description below.