 Japanese encephalitis, JE, is a viral neurological disease and disability in Asia that can lead to death or long-term sequelae in children. There are four types of JE vaccines, including the live-attenuated SA14-14-2 vaccine, LARGEV, which provides long duration of protection and is well tolerated across a wide age range. While serious adverse events attributable to LARGEV have been reported, independent experts have not found sufficient evidence for causality based on available data. This article was authored by Amy Sarah Ginsburg, Unka Tomeghani, Scott B. Holstead and others.