Why delayed onset of mental illness? Genes impact suspect brain areas late





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Published on May 20, 2014

Thickening of cortex areas implicated in mental illness shows increasing genetic influence as the brain develops in childhood and adolescence, NIMH researchers have found. These areas also happen to be the latest to evolve and the last to mature. The peak of genetic influence in these areas coincides with the typical age-of-onset of most mental disorders in late adolescence/early adulthood. The new findings may provide insight into the workings of gene-by-environment-by age interactions in the disorders, says Jay Giedd, M.D., of the NIMH Child Psychiatry Branch.
See: Genes increasingly impact suspect cortex areas as youth mature - http://1.usa.gov/1nfB3z4

Jay Giedd, M.D., Eric Schmitt, Ph.D., NIMH - MRI movies

Cristophe Lenglet, Ph.D., U. Minnesota -- DSI brain image

Van Wedeen, M.D., Harvard/MGH - DSI Animation

Brain & Behavior Research Foundation, http://youtu.be/CD-P68KIW-U - video clip

UCLA Laboratory of Neuro Imaging -- DSI animation from "Navigating the Connectome"

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