 This study investigated the efficacy of mindful sensoromotor therapy, MISMT, combined with transcranial direct current stimulation, TDCS, for treating neuropathic pain caused by highly impaired extremities or peripheral nerve injuries. Eight participants were recruited and received 12 sessions of MISMT with anodal TDCS in the motor cortex. The primary outcome was the change in pain intensity as measured by the pain rating index between the first and last treatment sessions. Results showed significant improvements in pain intensity after MISMT and TDCS compared to baseline scores. These findings suggest that MISMT and TDCS may be beneficial for treating neuropathic pain caused by highly impaired extremities or peripheral nerve injuries. This article was authored by Max Ortiz-Catalán, Shahad de Mercheli and Maccabist.