 Collagen is a major component of the extracellular matrix, ECM, which plays important roles in the regulation of the three phases of normal wound healing. It can be found in its native, fibrillar conformation or as soluble components in the wound milieu. Disruption of any of these phases can lead to impaired wound healing and require interventions such as collagen-based products to restore proper functioning. Collagen-based products have been used to promote wound healing by reducing inflammation, increasing destruction of ECM components, activating soluble mediators, and promoting angiogenesis. This article was authored by Shomida S. Matthew Steiner, Sushwati Roy, and Chandan Kasen.