 The arachidonic acid, AA, pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. It is metabolized by phospholipus A2, PLA2, cyprooxygenases, coxes, lipoxygenases, LOXs, and cytochrome P for 50, CYP, enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrains, LTs, epoxyacosatrinoic acids, EETs, dehydroxyacosatetrinoic acid, DIHETs, icosatrinoic acids, ETEs, and lipoxins, LXs. Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases, CVD, cancers, and inflammatory diseases. This review summarizes the physiological and pathophysiological importance of the AA metabolizing pathways and outlines the molecular mechanisms underlying. This article was authored by Bei Wang, Lu Jing Wu, Jing Chen, and others. We are article.tv, links in the description below.