 One health has become increasingly accepted as a way to tackle complex health issues. Its multidisciplinary approach to understanding the causes of disease outbreaks, as well as their prevention and control, makes it particularly useful when dealing with zoonotic diseases like Ebola virus disease, EBV. Understanding the risk factors associated with EBV spillover from animals to humans can help identify areas where interventions are needed, allowing for early detection and prevention measures to be put in place. Despite its benefits, One Health faces several challenges, including status, bias and power imbalances between different professions, as well as difficulties integrating environmental health and social science expertise. This article was offered by Rebecca Maudling.