 Thiosemicarbazones, TSC, conjugated with tripeptids were designed and synth-sized for the purpose of tyrosinase inhibition. The results showed that TSC1 conjugates exhibit higher inhibitory effects against mushroom tyrosinase compared to COGIC acid, a widely used reference compound. Furthermore, the in-silico analysis revealed that the difference in the activity between TSC1, conjugate and COGIC acid could be attributed to the different steric hindrance caused by the presence of the tripeptid moiety. This article was authored by Patrikia Ledwin, Waldemar Goldemann, Katazina Haldes, and others.