 WS3 is a compound used as a cooling agent for tobacco or nicotine products. It is one of four similar compounds, including WS23, Evercool 180, and Evercool 190, which all have cooling properties and can be used as tobacco additives. Previously reported methods for analyzing WS3 were relatively complex, so the goal of this study was to develop a simpler, faster, and more accurate method for simultaneously analyzing WS3 and the other three cooling compounds. To achieve this, a liquid chromatography mass spectrometry, LC-slash-MS, method was developed requiring only six minutes of run time. The method was then calibrated to analyze solutions, containing each analyte in the range of concentrations between 48.8 nanograms per milliliter and 12.5 mu G-slash-ML. Additionally, a gas chromatography mass spectrometry, GC-slash-MS, method was developed primarily for the purpose of having a proof of accuracy for both methods. This GC separation requires 20 minutes of run time. The GC-slash-MS technique was calibrated to analyze solutions containing each analyte. This article was authored by Moldaviano-Serban C and Bussey Robert O. We are article.tv, links in the description below.