 The National Center for Advancing Translational Science, NCATS, has recognized the importance of dissemination and implementation, D&I, sciences in advancing research translation. To address this need, NCATS established a D&I Sciences workgroup in 2016. The group proposed an integrated framework for understanding the roles of D&I sciences across the translational research spectrum. This framework proposes that D&I Sciences should be used to identify and investigate strategies for accelerating research translation at each stage of the translational research process. Additionally, the framework emphasizes the importance of D&I thought leaders in extending these principles to all research stages. This article was authored by Aaron L. Lepping, Jane E. Mahoney, Kathleen R. Stevens, and others.