 This study found that most residents in the Assur region of Saudi Arabia lacked adequate knowledge about monkeypox and were not confident in diagnosing and treating it. To address this issue, the Saudi Ministry of Health should organize conferences and educational programs on monkeypox to help healthcare professionals gain better understanding of the disease and become more confident in its diagnosis and treatment. This article was authored by Ali Muhammad Shafi, call it MLMOSA, Najmazi Al-Sharani, and others.