 Despite the anticipation of effective vaccines for COVID-19, vaccine hesitancy is widespread worldwide, with declining acceptance observed among certain demographics and socio-economic groups. Survey results vary and are influenced by factors such as perceived risk, concerns over safety and effectiveness, doctor recommendations, and inoculation history. Unique COVID-19 factors include political party orientation, doubts about expedited development slash approval process, and perceived political interference. To achieve herd immunity, communication campaigns focusing on transparency and restoring trust in health authorities are immediately needed. This article was authored by Cheryl Lynn, PQEI 2, and Leslie M. Beech.