 The study provides insight into the structure of voltage-gated sodium, nav, channels and how they interact with certain drugs. The researchers found that carbamazepine, bupivocaine and locosamide all bind to the same site underneath the intracellular gate, site Big. Additionally, they discovered that locosamide can plug into the selectivity filter from the central cavity. Furthermore, they identified two additional sites where drugs can bind, the 3-4 fenestration for vintpositine and hard wickic acid, and the IVI fenestration for vixotrigin. This information will help scientists better understand how these drugs work and how they can be improved upon. This article was authored by Chi-Reng Wu, Zhen Huang, Xiao Fan, and others.