 This study found that implementing universal and indicated school-based socio-emotional learning, SEL, programs could reduce the incidence of depression and anxiety and suicide deaths among adolescents. Universal SEL programs are estimated to generate 100 healthy life years, HLYGs, per 1 million population while indicated SEL programs are estimated to generate 5 HLYGs per 1 million population. The cost per HLYG for both types of programs ranges from 58 to for 73 depending on the country's income level. This article was authored by YY Lee, S Scheme, GJ Melendestorys and others.