 The results of this study suggest that spiritual well-being, perceived social support, health literacy and resilience are all significant factors in determining the quality of life of hemodialysis patients. Specifically, spiritual well-being, perceived social support and resilience were found to be strong predictors of physical quality of life, while health literacy was found to be a strong predictor of mental quality of life. Additionally, spiritual well-being, perceived social support and resilience were found to have greater impact on physical quality of life than the other variables. Therefore, it can be concluded that improving spiritual well-being, increasing social support, and enhancing resilience may help to improve the overall quality of life of hemodialysis patients. This article was authored by Fatemeh Hassani, Miriam Ghulamzadejafra, Karash Surya, and others.