 The tumor microenvironment plays a crucial role in tumor genesis by facilitating uncontrolled cell proliferation through interactions between malignant and non-malignant cells, including adipocytes, fibroblasts, lymphocytes, dendritic cells, cancer-associated fibroblasts, and cancer stem cells. Targeting these components of the tumor microenvironment during cancer treatment can help control malignancies and improve health outcomes. This article was authored by Boros Arneth.