 Our study found that apolidomide has been associated with several adverse events such as rash, fatigue, diarrhea, hot flush, fall, weight decreased, hypertension, lycanoid keratosis, increased eosinophil count, bacterial pneumonia, pulmonary tuberculosis, and hydranophrosis. These adverse events are mostly related to skin and subcutaneous tissues and can be managed by appropriate treatment. This article was authored by Chiang Phan, Chiang Su, Wei Zhu, and others.