 Jesus said this about living a meaningful life, but it's a complete opposite of everything our culture stands for. We embrace self-love, self-preservation that we come first, that we must self-actualize through the pursuit of our most intrinsic desires. But Jesus says this, You must lose your life for my sake to find it, to sacrifice yourself for the sake of Christ. But we can't do this on our own, it's not in our nature, we do everything in our power to preserve our life. But when we put our faith in Him, God gives us a new heart. We are being transformed into the person that God actually wants us to be. Greater love has no one than this that a person would lay his life down for his friend. But Christ did so much more than this while we were still enemies with Him, He laid his life down for us. A meaningful life is found when we receive God's good gift of salvation and through His power and love seek to exemplify a sacrificial life.