 Hey everybody, Dr. O, this video we're going to talk about the lipopeptide antibiotic called daptomycin. It's going to be a short video because there's only a real specific reason I want you to know this. It disrupts cell membranes similar to the polymixin antibiotics, but whereas polymixin like polymixin B and polymixin E, which is colostin, they only target gram-negative bacteria. This one's only going to target gram-positive bacteria, so it's an intravenous antibiotic. It doesn't have a lot of side effects, but when this would primarily be used would be to treat MRSA and VERSA. So MRSA is methicillin resistant staphylococcus aureus, VERSA is vancomycin resistant staphylococcus aureus. So vancomycin, which was supposed to be the last line of defense, now needs another last line of defense. So if vancomycin won't work, daptomycin is usually the next one that you would go to. So that's where the key thing here is to note that this can treat these superbug infections, these multi-drug resistant staph infections that we get primarily in the skin or but they can obviously get in the blood and those kind of things as well. So the main thing I want you to know really the only thing about daptomycin is this would be the one we'd pull out if vancomycin isn't working against staphylococcus aureus. All right, I hope this helps. Have a wonderful day. Be blessed.