 All the hypothesis combine with a new knowledge, combine with a new concept. And what we as scientists try to do is to combine all these new concepts to understand what leads to a disease and how I can cure that disease. And that is exactly how though the science turned around to start from one specific question that maybe give one specific answer to find the real mechanism to treat some untreatable disease. So the combination of those concepts can generate the information needed for trying to improve one already treated disease but make it faster or even better recovery or with less clinical adverse effects or just trying to find the answer for untreatable diseases. In the cardiovascular field it's very important this kind of new discoveries because the heart it's a very unique organ because the cells that you have when you were born is almost the same number of cells that you have when you die. So we need to protect the cells or we need to find a ways that to go around the nature and create new cells that we call cardiac regeneration. So that is two approaches like how can I protect myself or how I can generate new cells. So those are two new approaches that cardiovascular is trying to focus now using the hypothesis to understand, to create concepts for incorporating some of new concepts to the idea and going around the already established knowledge. To discover new and better approach for the health and keep us healthy and safe.