 A new topical panthenol containing emollient, NTPCE, was evaluated in two randomized, intra-individual comparison studies in healthy subjects for its skin moisturization and barrier restoration potential, as well as its effect on skin microflora. In study one, NTPCE use resulted in statistically significant improvements in TWL reduction, stratum corneum hydration, and an increase in mean ICLL length from baseline. In study two, NTPCE use had no negative impact on bacterial viability. Overall, NTPCE use has favorable and lasting effects on barrier function and repair as well as skin hydration without negatively influencing bacterial viability. This article was authored by Hans Stepler, Peter Kerker, Natalie Lunow, and others.