 Abstract colongeocarcinoma, CCA, is a rare but deadly form of cancer that is difficult to detect in its early stages. Current diagnostic methods are limited and do not offer reliable results. Researchers have developed a novel nanoplasmonic sensing technology called FLEX, fluorescence-amplified extracellular vesicle sensing technology, which can detect CCA with greater accuracy than existing methods. This technology uses gold nanowells to capture and amplify the fluorescent signal of extracellular vesicles, allowing researchers to detect even small amounts of these vesicles that would otherwise be undetected. The FLEX technology has been successfully tested on clinical bile samples and was able to accurately detect CCA with an area under the curve of 0.93, indicating a higher degree of accuracy than other existing methods. This article was authored by Miho Jong, Taewang Sun, Yukung Tae, and others.