 Metformin has been shown to be safe for patients with type 2 diabetes mellitus, T2DM, and chronic kidney disease, CKD, with no evidence of increased risk of AKI. However, more research is needed to determine the optimal dosage and duration of treatment for patients with varying degrees of CKD. This article was authored by Mohsen Akhaven-Sepahi, Bhaskar V.K.S. Lakkakula, Stephen James Kellner, and others.