 Type 2 diabetes, T2D, is characterized by impaired insulin secretion, and reduced pancreatic beta-cell mass. Recent studies have shown that the phosph pigeons, transfer protein alpha Wouldna plays a key role in insulin granule maturation and docking, which is essential for proper insulin secretion. In this study, researchers found that pit過去 levels were significantly lowered in the beta cells of patients with T2D compared to healthy controls. When PIPNA was restored in the beta cells of T2D patients, it led to improved insulin secretion and increased beta cell mass. These findings suggest that PIPNA may be a potential therapeutic target for treating T2D. This article was authored by UTE Year, Chandan Sona, Xin Yang, and others.