 The Cure Americas, Guatemala Maternal and Child Health project was successful in improving the health and well-being of children and women in the Department of Hulhuitinang. The project used a combination of three approaches, the census-based, impact-oriented, CBIO approach, the care group approach, and the community birthing center, CASA Maternal Rural approach, to improve access to health services and increase knowledge about maternal and child health. The project also provided training to local women volunteers who then educated their neighbors about key health topics such as maternal and child health, nutrition, prevention, and treatment of acute respiratory infections and diarrhea in children, and immunizations. As a result, the project saw improvements in 21 out of 24 indicators related to these topics. This article was authored by Stanley Blanco, Mario Valdez, IRA Stollack, and others.