 The study presents the rat grimace scale, which is a reliable and accurate tool for quantifying spontaneous pain in laboratory rats, and demonstrates its ability to measure time course of pain, dose-dependent analgesic efficacy of morphine, and automate the most labor-intensive step-through software called Rodent Face Finder. The study suggests that widespread adoption of spontaneous pain measures may lead to more successful translation of basic science findings into clinical application. This article was authored by Jean-Chu, Wei-Peng, Mapelbeck, Josiane C.S., and others.