 Brain-controlled wheelchairs are a promising technology for those with severe physical disabilities or locked-in syndrome. In this study, 10 participants with spinal cord injury successfully completed 10 tasks using AP300-based brain-controlled wheelchair. No significant changes in vital signs were observed, suggesting minimal physiological and cognitive burden. Additionally, the task load did not increase significantly, indicating that the proposed brain-controlled wheelchair is safe and reliable. This study provides evidence that brain-controlled wheelchairs could be used as a viable option for those with severe physical disabilities or locked-in syndrome. This article was authored by Xie En-Chun, Yang Yu, Ging Cheng-Tang, and others.