 Abstract a low-cost microfluidic platform integrated with a flexible heater was developed for Institute temperature-dependent spectroscopic measurement at the point of care. After verifying the system by comparing on-chip spectroscopic measurement of methylene blue with the conventional spectroscopy, we demonstrated its applications in temperature dependent absorption spectroscopy of a model biomolecule, curcumin. The system is portable, battery-powered and requires ultra-low volumes of analytes, which is highly suitable for point-of-care characterization. This article was authored by Saikrishna Katla, WAN Ju, Hamta Vakali and others.