 The World Health Organization's WHO choice approach is a unique cost-effectiveness analysis tool that can help countries prioritize their health care spending. It provides a general framework for evaluating the cost-effectiveness of different health interventions, allowing for comparison across different regions and countries. Additionally, it offers tools to support country-level analyses and provide more detailed information about specific interventions. Finally, the WHO choice project has updated its methodology and provided five papers covering maternal, newborn and child health, HIV, TB and malaria, and non-communicable diseases and mental health. These papers demonstrate the potential of the WHO choice approach to inform policy decisions related to health care spending. This article was authored by Melanie Y. Bertram and Tessa Tentora's editor.