 This paper considers the stability of a fractional differential equation with multi-point boundary conditions and non-instantaneous integral impulse. Some sufficient conditions for the existence, uniqueness and at least one solution of the aforementioned equation are studied by using the Diasmar Golis fixed point theorem. Secondly, the ULM stability of the equation is also discussed. Lastly, we give one example to support our main results. It is worth pointing out that these two non-instantaneous integral impulse and multi-point boundary conditions factors are simultaneously considered in the fractional differential equations studied for the first time. This article is authored by Guodong Li, Yin Zhang, Yajuan Guan, and others.