 Artificial intelligence, AI, is a broad term referring to the use of technology to mimic human intelligence. It can be divided into two main categories, machine learning, ML, which involves computers drawing conclusions from data without being explicitly programmed, and natural language processing, NLP, which uses algorithms to interpret and understand text. ML has been applied to many areas of healthcare, including triage, diagnosis, treatment, and discharge. For example, ML models have been developed to help identify patients who are likely to develop sepsis or to predict the time until a patient will experience a severe form of pneumonia. Additionally, ML has been used to classify patients' COVID-19 severity levels and to determine the best course of action for their care. The increasing availability of EHR data and computing power provide opportunities for ML to improve patient safety, streamline clinical workflows, and reduce healthcare costs. This article was authored by Alisa J. Hamilton, Alexandra T. Strauss, Diego A. Martinez, and others.