 Host defense peptides, HDPs, are promising agents for infection diseases due to their broad spectrum and low resistance rate. However, they are limited by proteolytic instability, high cost, and complex synthesis processes. A new type of HDP mimicking beta peptide polymers were developed to overcome these limitations. These polymers resist proteolysis, have enhanced antimicrobial efficacy, and are low cost to produce. They can also block bacterial communication and disrupt bacterial membranes, leading to improved biofilm eradication and virulence reduction. This has led to improved therapeutic effects in Pseudomonas aeroginosa pneumonia and Escherichia coli pyogenic liver abscess. Overall, this study demonstrates the potential of beta peptide polymers as a novel class of HDPs with great clinical potential. This article was authored by Juan Linli, Xinyan Xiao, Yuchen Qi, and others. We are article.tv, links in the description below.