 Praying in the Holy Spirit is praying in harmony with the will of the Holy Spirit, with the guidance of the Holy Spirit, and in the power of the Holy Spirit. To pray in the Holy Spirit is to pray in cooperation with the person of the Holy Spirit, to pray according to his will, to pray according to his leading. And in order to do this, we have to be sensitive to the person of the Holy Spirit. We have to be listening for that voice.