 This study examined the effectiveness of two treatments, metformin and curcumin, in reducing oxidative stress in the kidneys of diabetic rats. Metformin was found to be more effective than curcumin in restoring the antioxidant capacity and total oxidant status of the kidneys. However, both treatments were able to reduce the level of urinary creatinine, urea, and protein, indicating that they are effective in treating diabetic nephropathy. This article was authored by Sohaila Asadi, Mohamed Taghi Gadarzi, Jamshiv Karimi, and others.