 osteosarcoma is a common form of cancer that primarily affects teenagers and young adults. It is caused by malignant mesenchymal stem cells, which can be found in the bones of patients with osteosarcoma. The disease is characterized by the presence of fibroblasts, osteoblasts, osteoclasts, and immune cells, all of which interact with each other to promote tumor growth. Additionally, extracellular vesicles, EVs, which are small membrane-bound packages containing various biomolecules, are also present in the osteosarcoma environment. These EVs are thought to play a key role in the development and progression of the disease. Furthermore, EVs may provide a means for osteosarcoma cells to communicate with other cells in the tumor microenvironment, potentially leading to metastasis and drug resistance. Finally, recent studies suggest that EVs could be used as diagnostic tools and therapeutic targets for osteosarcoma. This article was offered by Yi Liao, Chen Yi, Jin Long He, and others. We are article.tv, links in the description below.