 The study examines the evolutionary dynamics of polymorphic pseudomonas originosa populations in patients with chronic obstructive pulmonary disease, copped, and finds that isolates deficient in production of shareable extracellular products are sequentially selected, with LASAR mutants appearing first due to their quorum-sensing defects. Polymorphic populations including LASAR mutants display survival advantages in animal models of infection and modulate immune responses, shedding light on the multistage evolution of p-originosa populations during their adaptation to host lungs. This article was authored by Kalei Zhao, Ziting Yang, Zhang Lanzang, and others.