 Emerging SARS-CoV-2 amicron sublineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, carnitols show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pronounced in vaccinated individuals. This article was authored by Khadija Khan, Farina Karim, Yoshika Gonga, and others.