 Hi, everyone. I'm Xing Guoliou, PIN professor in Guangzhou Institute of Medicine and Health, Chinese Academy of Sciences. We just published a paper in stem cells about lipid metabolism regulator, SRP-P1, in the reprogramming. And we know that during reprogramming, from somatic cell to RPS, the lipid metabolism always changes. So, while attempting to know the mechanism, we found that SRP-P1 shows huge increase about the end-level and its truncated performance also gets a huge increase. So, we want to know how the effect of SRP-P1 in reprogramming. And we found that it can enhance SQM, but not SKO-induced reprogramming. And also, SRP-P1 complements the partial reprogramming cells for RPS. And silencing inhibition by drugs will prevent reprogramming. As SRP-P1 enhancing reprogramming must occur in presence of CMake, then we ask how SRP-P1 and CMake cooperation would be involved in reprogramming. We found that these two proteins can regulate the collection and interrelated sets of genes via microarray data. For mechanism, we show that it's an SRP-P1 formation or Y329R mutation that can enhance reprogramming would interact with CMake directly by co-IP experiments. We also performed GST true-down to show that these two proteins can interact in ritual. It has been reported that CMake can enhance YAMLAC factory's binding, so we first show that in presence of SRP-P1. CMake is more readily binding to opt for promoter, and also SRP-P1 can enhance the binding of SQM to their co-binding sites. We know that encroaching CMake is double-edged source in reprogramming, not only enhancing reprogramming, but can induce tumourine generating. So we test how the fact of SRP-P1 in M-Make, YAMLAC, or the CMake-W136E mutation and all the three has a little transformation activity. Our data shows that SRP-P1 can enhance all these three conditions, indicating that its effects on reprogramming is independent of M-Makes transformation activity. So in summary, SRP-P1 can interact with CMake directly and strength the co-binding of YAMLAC factory to their sites and facilitate the activation of M-Make targets and then enhance the IPS generation sites. Thank you.