 Epithelial mesenchymal transition, EMT, is a process by which cells lose their epithelial characteristics and gain mesenchymal characteristics. It is involved in embryonic development, wound healing, and tumor progression and metastasis. During EMT, cells expand out of the surrounding environment and express proteins such as alpha-SMA, FGF, FSP1, and collagen to further differentiate into mesenchymal cells. Additionally, EMT is not solely dependent on EMT regulators like Snail, Twist, and Zeb1-2, but rather requires upstream signaling pathways such as TGF-beta, EGF, and WNT for full activation. Furthermore, tumors can induce fibroblasts to undergo EMT, which can lead to increased tumor aggressiveness and metastatic potential. Finally, this review discusses how fibroblasts in prostate cancer can interact with tumor cells to promote metastasis and recurrence after treatment. This article was authored by Bethany N. Smith and Neil Abomic. We are article.tv, links in the description below.