 Our study found that obese people who consume more fat have higher levels of the hormone GLP-1 in their small intestines. This suggests that GLP-1 may play a role in helping these individuals better manage their blood sugar levels. Additionally, our research showed that mice fed a high fat diet had an increase in GLP-1, producing cells in their small intestines and colons. This suggests that the increase in GLP-1 production may help these animals better control their blood sugar levels. Our findings also indicate that this effect is likely due to an increase in the number of GLP-1 producing cells rather than an increase in the amount of GLP-1 produced by each cell. Finally, we discovered that the increase in GLP-1 producing cells in the small intestines and colons of mice fed a high fat diet was caused by an increase in the number of cells expressing the gene NGN3 which is necessary for the development of GLP-1 producing cells. Taken together, our results suggest that the increase in GLP-1 producing cells in the small intestines and colons of up. This article was authored by Thomas Arranias, Alexandra Grossfeld, Christine Poitoux, and others.