 Acupuncture is a traditional Chinese medicine practice which involves inserting thin needles into specific points on the body. It has been shown to have beneficial effects for various diseases and painful conditions, making it a popular alternative treatment option. Research suggests that acupuncture may work by stimulating the release of certain chemicals in the body, such as calcitonin gene-related peptid, CGRP, which can reduce inflammation and relieve pain. Additionally, acupuncture may also affect the levels of other chemicals, such as beta-endorphins and neurotransmitters, which can further reduce inflammation and pain. This article was authored by Freak J. Zijistra, Inaka Van Den Bergdellanger, Frank J. P. M. Higan, and others.