 Excitation-contraction coupling requires a specialized membrane structure called the triad, which consists of a plasma membrane invagination, PMI, the T-tubule, and two sarcoplasmic reticulum terminal cisternae, SRTCs. The exact mechanism for how this structure is formed remains unclear, but it has been suggested that cavioli are involved in its formation. Mutations in genes associated with cavioli can cause muscular weakness and myopathy. In this study, researchers found that bin 1 and cavioli interact to form a ring-like structure, which then becomes the foundation for the t-tubule. They also discovered that bin 1 is necessary for the formation of the t-tubules, as well as for the proper distribution of cavioli. Finally, they showed that cave 3 deficiency causes disruption of the ring-like structure and impaired t-tubule formation, suggesting that this could be a potential cause of myopathy. This article was offered by Aline Limo, Jean Lane, Marion Benoist, and others. We are article.tv, links in the description below.