 This study investigated the effect site concentration, SU, of remamazalam at loss of response, LOR, and recovery of response, ROR, in patients undergoing general anesthesia using simulation. Additionally, the relationships between patient factors and simulated SU at LOR and ROR were examined. Remamazalam was administered as an induction dose of 6 or 12 mg per kg per hour, until the patient became unresponsive, followed by 0.3 to 2 mg slash kg slash h to maintain bespectral index, BIS, values below 60. Simulations of manual infusion mode were performed using ASIN pump software and the SU of remamazalam was simulated, using the Schutler model. Whenever infusion rate of remamazalam was manually changed, the simulated SU was confirmed almost simultaneously. The median, 1q, 3q, simulated SU at LOR and ROR were 0.7, 0.5, 0.9, and 0.3, 0.2, 0.4, g slash ml, respectively. LOR was achieved in one. This article was authored by Kim Mi Kim, Ji Yun Bang, John Min Lee, and others. We are article.tv, links in the description below.