 Neurodegenerative diseases pose a significant threat to public health, but there is currently no effective treatment available. Research into neurotrophic factors such as BDNF has shown promise, but its limited stability and short half-life in the body have hindered its use as a therapeutic agent. Several strategies have been developed to overcome this issue, including the use of polymer-based carriers, lipid-based particles, and nanoparticles. These advances offer hope for the development of more effective treatments for neurodegenerative diseases. This article was authored by Claire Gerald, Angelina Angelova, and Sylveon Lessir.