 Skin serves as a barrier against external agents and helps prevent fluid loss and trauma. It consists of three main layers, the epidermis, dermis, and subcutaneous fat layer. These layers are composed of various cell types including keratinocytes, fibroblasts, and adipocytes. Damaged skin must be repaired and regenerated after injury, and skin substitutes are used to cover large areas of damaged skin. There are several types of skin substitutes, including acellular skin substitutes, those with cultured epidermal cells, and those with both epidermal and dermal components. Wounds heal through fibrosis, and fibroproliferative disorders like hypertrophic scarring and keloids can lead to cosmetic and functional issues. Studies suggest that superficial dermal fibroblasts may be more effective at promoting healing than the conventional heterogeneous dermal fibroblasts. This article was authored by Matthew Varkey, Jia Ding, and Edward E. Tregit. We are article.tv, links in the description below.