 Abstract the COVID-19 pandemic comes across the gradual rise of the influenza virus, and the co-circulation of the two viruses is inevitable. The dangers of co-infection are becoming clearer, but the disease burden of co-circulation in the near further is unknown. In the intersection era of big data and machine learning development, it is important to distinguish the impact factors of co-prevalence and apply appropriate methods to advance projecting future risks. This article was authored by Jingyi Liang, Zhichizeng, Qianying Li, and others.