Dance Your PhD 2009 - Dance of the Migrating Neuron




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Published on Nov 13, 2008

Too many late nights in the lab?

Entry for the 2009 AAAS Science Dance Contest

Title: Adhesion and Endocytosis in Neuronal Migration

Jennifer Shieh
Graduate Student
Stanford University

The dynamic dance of the nomadic neuron begins at birth.

Act I: Interkinetic Nuclear Migration
In the cerebral cortex, neural progenitors divide to give birth to more cells at the surface of the ventricle (the fluid-filled hole in the middle of your brain).

Act II: Indecision
The newborn cortical neuron migrates out to the surface of the brain, attracted and repelled by various guidance cues. These neurons pass through a multipolar stage where they may be deciding what direction to go or where to project their axon.

Act III: Directed Radial Migration
The physical movement of a neuron is much like the old PE rope-climbing exercises. A hand-over-hand extension of the leading process that must stick to a radial glial guide, followed by the thickening of part of the cytoplasm in front of the nucleus, and finally the forward movement of the cell body. For the cell body to move forward, adhesions must be weak. Endocytosis, the internalization of bits of membrane, might help weaken those adhesions, allowing the cell to let go and the cell body to move forward.

Act IV: Finding Your Fate
Once the neuron reaches its final destination, it can fulfill its fate and take its place as a fully functioning member of the brain.

Song: "Let Go" by Frou Frou

  • Category

  • Song

  • Artist

    • Frou Frou
  • Writers

    • Guy Sigsworth, Imogen Heap
  • Licensed to YouTube by

    • UMG (on behalf of Universal-Island Records Ltd.); UMPG Publishing, UMPI, LatinAutor, UNIAO BRASILEIRA DE EDITORAS DE MUSICA - UBEM, CMRRA, LatinAutor - UMPG, ASCAP, and 10 Music Rights Societies


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