 The urgent need for an effective COVID-19 vaccine has led to the exploration of adjuvants, including saponins, which can enhance protective immunity and stimulate both TH1 type immune response and cytotoxic T lymphocyte production. Saponins have shown promising results in sub unit vaccines against intracellular pathogens and could be useful for a SARS-CoV-2 vaccine. This article was authored by Rin Kishama, Aravakarasi Pulanisomi, Kaldip Dhamma, and others.